glucagon and weight loss

Is it more than coincidence that here in America, where the necessity of breakfast is repeated ad nauseum as well as three squares a day and snacks, that we have an epidemic of obesity?

Learn the secret to utilizing your own glucagon, the only human metabolic path to safe and permanent weight loss.

eat breakfast ... get fat!
metabolic fantasies tiny motors
three meals a day ... at least one too many!

The following paragraph is from the website: weightcontrolforever.com

"To start with make sure breakfast is eaten every day and a healthy breakfast at that. Skipping breakfast is not what anyone looking for weight loss fast tips should be doing. Eating a healthy breakfast will kick start the metabolism when you wake, after it has slowed down at night time. Think of it this way, your metabolism is like a furnace, it has to be fed with fuel so as to work at its optimum best. So get your metabolism working once you wake with some fruit, cereals and a glass of water and it'll begin burning fat straight away."

end of rubbish from "weightcontrolforever.com"

metabolic fantasies
wishful pseudo science

Just another in the plethora of mis-information on the web. Note the complete lack of any "science." There are no references for these nefarious statements -mainly because there is "No Science" to support them. This is simply "wishful pseudo science and metabolic fantasy." People looking for any reason real or imagined that justifies their "appetite out of control." Probably one of the biggest reasons today for the "epidemic of obesity" is this type of self-schooled pseudo science. People speak of "metabolism" with virtually no understanding of what they are talking about.

metabolism 101
which metabolism are we talking about

The human body has many "metabolisms." In Stryer "Biochemistry" there are 344 pages on metabolism including twenty-eight pages devoted to Biosynthesis of Membrane Lipids and Steroids, twenty-six pages devoted to the "metabolism" of amino acids, twenty-four pages devoted to the biosynthesis of nucleotides and another twenty-three pages devoted to integration and regulation of metabolism.

Let's take a look at some real metabolisms. I took biochemistry back in 1964 so I will take the liberty of using a more recent standard reference book:

Stryer Biochemistry 4th Edition
page 773 Hormonal Regulation of Fuel Metabolism

Lubert Stryer is professor of biochemistry at Stanford. I think that this should serve as a reasonably accurate reference. We will begin with a brief discussion of the metabolism of energy utilization (weight loss glucagon weight gain insulin). Energy utilization or what your body does with food when you eat it and when you don't comes under hormonal regulation by two pancreatic proteins insulin and glucagon.

what happens when you eat?

As the ingested food is assimilated your blood sugar goes up. This is followed by a rise in your serum insulin level. Insulin is the hormone that is responsible for entry of the glucose into your cells and conversion (storage) of any excess into fats. This is part of the rather elegant biochemical system that allowed man to survive famine. This is what happens when we eat -period. If you eat human digestible foods (not cellulose) your insulin levels will rise no matter what any pseudo scientific gurus try to tell you otherwise. The only metabolism that increases when you eat is the metabolism of energy storage (makes fat!).

straight away ... to storing more fat -not burning it

Insulin levels will go up whether you eat in the morning, afternoon or evening. This is human biochemistry -you can't change it nor can I. The only thing that will happen straight away after your breakfast of fruits, cereal and water is that you will start storing fat -just the opposite of burning fat.

what happens when you don't eat?

Two to three hours after you have eaten, the insulin level should return to the normal fasting level. As the insulin level is coming down, the glucagon level is starting to go up. Insulin is the storage mechanism for the human, glucagon is the biochemical path to utilize this stored energy. The human species has evolved because of these two hormones, insulin and glucagon. Insulin is the gas pipe from the fuel tank in your car to the filler pipe opening on the outside. Insulin stores energy and fills your tanks (liver, muscle and fat cells) with energy.

glucagon is your motor

Glugacon is the motor that takes all this stored fuel (energy) and burns it to move the car (your body) or any number of other fuel (energy) requiring tasks. Each of these are independent reactions (metabolisms). Thus we have the metabolism of energy storage (insulin) and the metabolism of energy utilization (glucagon).

warning: rubbish ahead

Now it is clear that the above paragraph from the website weightcontrolforever.com is at best wishful thinking about "metabolic fantasies." Note that they address only your "metabolism." They do not state which metabolism this is. Is this the metabolism of insulin or is this the metabolism of glucagon? You now can understand that they are talking about two different metabolisms. The metabolism while you are sleeping (glucagon) and the metabolism that allows you to store your recently ingested meal as energy (insulin). It sounds good though ... "your metabolism is like a furnace" when what they mean to say is that your glucagon metabolism is like a "furnace." This furnace they talk about will "never" have a fire in it if you eat all the time. You won't burn "calorie one" since you will always be in an insulin "fed" state storing all your recently ingested energy. It is impossible to burn calories when the body (insulin) is busy storing them.

tiny motors
enzymatic induction
use it perfuse it or lose it!

Continuing with the automobile analogy most of us never utilize the engine in our car (glucagon). We fill up our tanks with three meals a day and snacks until there is no more room in our car. We never turn on the engine (glucagon) because we never go without food long enough for this motor to start. What happens is that over time our motor becomes smaller and smaller so that when we need to use it -it is barely able to start. This is enzymatic induction, one of the principles of human biochemistry. Human biochemical reactions are catalyzed by enzymes and in most cases they are not substrate dependant.
Translation: you can have a whole body full of energy (fat) and not be able to burn any of it for fuel in your motor (glucagon).

two things at one time

Human biochemistry does not like to do two things at the same time. It does not like to be storing energy while it is trying to utilize it. Thus experienced runners know not to eat before a marathon despite the current media blitz on how you should eat one of the myriad "bars" of some variety before the start. Eating before the start of an event puts you into an insulin (fed) state which is exactly the opposite of where you want your biochemistry to be when asking it to support your locomotion efficiently. No small wonder that the last American runner to win the Olympic marathon was Frank Shorter at Munich in 1972 (BG)(before gatoraid).

thirty days to starvation
gastronomic incompetence

The human will not really begin to starve until some thirty days after his or her last meal. The biochemistry of the human will keep you going for a long time without food. This is the main reason why man evolved. Without this ability I wouldn't be writing this, nor would you be reading this. However, man's internal drive to feed himself does not translate well into this age of "gastronomic incompetence." With fast food on every corner and the idiotic notion that we need "three squares and snacks" to survive -it is no wonder we have this epidemic of obesity. You won't starve for thirty days -much less if you miss one or even two of your three meals a day.

don't become "insulinated"
reduce insulin increase glucagon

You have to take your ego out of the equation, use all that gray matter between your ears and realize that this is all very simple, and it is us who have made it complicated. Most of us cannot feed our faces all day keeping us in an insulin state, and not get fat. Life in the insulin state is not fun. You don't have to look very far to see this. People completely encased in fat. Life seems to me to difficult enough without having to contend with your body being completely packed with fat. Maybe I'm wrong but I don't think it would make anyone "happy."

the scales won't lie

Don't believe this? Try this. Don't eat before noon and not after 1:00pm or at the latest 2:00pm. This gives you one hour (2 hours) to eat whatever you want. You will be in an insulin state only once every twenty-four hours. Do this for thirty days. You will be amazed at how much weight you will have lost and how much better you feel. The human is simply not meant to bathe his or her cells in insulin all the time and never call on our glucagon to utilize this stored energy (mostly stored as fat).

so what about breakfast

Almost all people will be healthier and slimmer if they enter into a state of glucagon metabolism sometime everyday. It is after all our "furnace" where we do actually burn fat. But if we never light that furnace by going without food for at least three or four hours, we will never burn any fat. Not that there is not the occasional person that seemingly can eat all the time and not gain weight. I used to know two of these types, but one had a heart attack at age 62 and died in December of 2008. He was always thin and ate a lot of highly sugared "healthy" snacks. Now, I only know one.

health weight loss

Most people I think may be more concerned with weight loss than health. But, if you eat to be healthy -your weight will drop to what it should be. When I became vegan in 1977 I lost weight and ate what I wanted. Former President Clinton experienced the same when he went to a plant based diet because of his coronary (arterial) heart disease.

productive mornings

One optimal time to burn some fat is when your glucagon metabolism is already burning -in the morning when you wake up. I get up, run and then work until noon. That gives me at least fourteen glucagon hours (I don't eat after 10:00pm). Often times I will get to two or three in the afternoon before I even think about food. It is easily the most productive time of the day for me. I guess if you could eat breakfast and lunch and then not eat until the next morning you could get 14-16 glucagon hours.

eat a light breakfast -skip dinner
eat a light dinner -skip breakfast

Whichever way you choose the basic three meals a day is at least one meal too many and certainly you will not fall off of the edge of the earth if you don't eat breakfast. I would also like to emphasize that your main meal of the day either way, should be your noon time meal. If you can skip dinner then eat a light breakfast and if you skip breakfast, eat a very light dinner. The bulk of your calories should be consumed at noontime. Whatever your approach, try to get at least 12-14 glucagon hours every 24 hours.

remember -weight loss is easy

The MericleDiet and The Metabolism of Weight Loss help intelligent but overweight and out of shape people quickly gain control of their weight, health and fitness for life in 30 days or less no matter how many times they have failed on previous diet and exercise programs.

Learn The Real Truth About Weight Loss

There are two main hormones that regulate weight gain and weight loss, INSULIN and GLUCAGON, and both are secreted by the pancreas.

Your own GLUCAGON secreted by your own pancreas is the only human metabolic pathway for weight loss.

The Metabolism Of Weight Gain And Weight Loss Is The Metabolism Of Insulin And Glucagon Respectively.

Just because you don't have a degree in Chemistry doesn't mean you can't understand how the human body regulates energy storage and utilization.

You will never be confused again about how to control your weight and some of the claims made by the current "dietary fads."

Phony Diet Claims

• Now you can lose weight sitting on your sofa.

• Eat More ... Weigh Less

• Activate your "Metastat"

• Lose Weight By Eating Seven or More Meals per Day

• Eat More Meat ... Secrete Less Insulin
  

• Increase Your Metabolism ... by Eating More

Don't Buy Any Diet Plan
Until You Understand How The Human Body Metabolizes Food

How To Lose Weight and Burn Fat
According to Real Human Metabolism

For example: The low-carb diets (Atkin's, Zone) had as one of their basic tenets that you would secrete less insulin by eating more protein (meat) and less carbohydrate. The problem was they never studied this notion and in fact the reality is just the opposite. It has been shown in a study reported in American Journal of Clinical Nutrition 50(1997):1264, that beef raises the insulin level as much if not more than any other food!

If it sounds too good to be true ... it usually is!

From "Secret Fat Loss Methods" to "losing weight by not eating less but eating more the Meta-Stat" to losing weight by eating seven or more meals a day, diet pills and weight loss surgery all have one common thread -they totally ignore human biochemistry. There is not one study in the literature that shows that by eating more food your pancreas will secrete less insulin. In fact the more you eat, the more insulin will be secreted. The more insulin that is secreted, the more energy will be stored as fat somewhere on your body with or without any so-called metabolic thermostat (Meta-Stat) in your brain. The "exercises" that are supposed to flip your switches to fat burning won't come anywhere close to utilizing all the energy(calories) you ingest in your seven meals a day.

There are two main hormones that regulate energy metabolism, insulin and glucagon, and both are secreted by the pancreas, not the brain.

What is important is that when it comes to human energy metabolism the hormonal control by the pancreas (not the brain) is what and only what decides how the recently consumed energy will be stored and or eventually utilized. There are no studies that show that by having any kind of diet surgery or taking diet pills, your nutrition improves. Usually just the opposite occurs -your nutrition really suffers and you become malnourished.

Your glucagon secreted by your own pancreas
is the only human metabolic pathway to burn fat.

The human body can lose weight and burn fat by one and only one pathway, no matter what all the hype on the web tries to tell you. Understanding the real math on this makes it much easier to control your weight. Insulin stores energy, glucagon utilizes it. The first concern of any diet plan should not be weight loss -it should be achieving optimal health through a series of lifestyle changes.

Endorsement

Dear Dr. Mericle,

I want to thank you for your excellent paper, "The Metabolism of Weight Loss." You have explained the fundamental processes that regulate weight gain and loss in very understandable terms. I am not a scientist but after (I confess) a couple of careful readings I now understand how and why I have struggled with weight. Since reading the e-book several months ago I have used the knowledge every day. Between this understanding of my body and the recommendations contained in the Mericle Diet I now feel confident enough to say that I have control of my eating habits and my weight. Thank you again!

Sincerely,
Patti M.
Ithaca, NY

The Two Things That Any Weight Loss Plan Has To Address!

• Regulate Insulin

• Maintain Adequate Nutrition

Optimal health will follow if the these two items are accomplished. Optimal weight loss will be a byproduct of optimal health. These two are the direct result of controlling insulin and achieving maximal nutritional density most of the time. This has to become "lifestyle change" in order to be effective. Temporary change, as is all too often typical for most weight loss plans, will almost always revert back to previous habits, increase in weight and increased risk of disease and less than optimal health. Several weight loss plans that violate these rules would be the Atkin's diet (poor nutrition), any low-carb diet (poor nutrition) and multiple small feedings (excessive insulin). Surgical procedures and diet pills also fail due to the lack of any real nutrition. One cannot ever be expected to achieve good health and safe and permanent weight loss without ever ingesting real nutrition necessary for vital life functions.

No Matter What Weight Loss Plan You Are On

It doesn't matter what weight loss plan you are on. People have tried everything from your blood type to multiple small feedings to sell diet products. Basically some of the most popular diet plans simply tell you what you want to hear -you get to eat everything you want to eat and a lot of it. Dr. Atkins made a small fortune by doing this while the people who bought this plan paid for it with increased morbidity and mortality from disease. Once you understand how the human biochemistry works, you won't get fooled by these diet plans.

No Matter What Type of Food You Eat

It doesn't matter if you eat meat, dairy, vegan, vegetarian, Chinese or Mexican. All food that can be processed by human energy metabolism must follow the same biochemical pathways that have been established since the human began to evolve. Human energy metabolism might be considered anachronistic in this age of fast food on every corner, but it is what it is and it is what we have. We can't change that nor can the GatorAid Sports Science Institute, the Atkins Diet, Multiple Small Feedings or any of the myriad plans out there today.

You Need This Knowledge

Trying to lose weight without fully understanding how the human body manages the calories / energy you eat is like trying to play professional football without knowing any of the plays. You may get lucky and lose that occasional pound, but the chances of you achieving your ideal weight and staying there, approach zero at the speed of light. It really doesn't matter whose diet plan you are on, excessive calories are still excessive calories. They become energy that your body doesn't utilize and insulin will soon store them as fat.

Endorsement

Dear Dr. Mericle,

Please do not send the refund check. I woke early this morning and re-read the document. It is excellent! Yesterday, when I read it over--it just seemed to be similar information I had read before. Once I really tried to understand, the second reading became very clear. I am very thankful to you for your work and also being so responsive to my email.

All my best to you,
Jane S.
New York, NY

from a second email a month later

Thank you so much Dr. Mericle,

This virus was a tough one. I ended up buying a new computer on Saturday, but I don't mind -- the new one is much better.

Thank you for all the links below. Everything is going great and your knowledge has helped me to understand how food interacts with my body and what I can do to control my weight. I am not currently overweight, but have always dieted. Now I don't have to diet, because I understand the chemisty and I am in control since I know how the body works.

I am so thankful to you.

All my best,
Jane

The Infinite Monkey Theorem

The Infinite Monkey Theorem states that if you put one hundred monkeys on one hundred typewriters eventually, given enough time, they would produce the complete works of Shakespeare. I am sure that as I write this there are at least one hundred monkeys working on another hundred diet plans dedicated to making someone a lot of money and relieving you of the burden of ownership of your wallet. The only way for you the consumer to be able to spot the real imposters is by knowledge. That knowledge can be quickly obtained by completing the Short Course on the Metabolism of Weight Loss.

Learn About Glucagon -The New Wonder Drug Secreted by Your Own Pancreas

• retards aging
• burns fat
• proven to reverse disease
• increases energy
• no harmful side effects
• 100% natural
• low cost ie no cost
• no prescription required
• available to all
• Secreted By Your Own Pancreas

Don't Become Insulinated!

While your insulin is working overtime, your glucagon is standing around in the unemployment lines.

Stop and ask yourself these questions!

• Are you tired of dieting?
• Are you tired of worrying about your weight?
• Are you tired of worrying about cancer, heart disease and stroke?
• Do you have adult onset diabetes?
• Are you worried about osteoporosis?
• Would I rather not worry about all this?
• Do you look as good as you could?
• Do you want to eat a healthier diet but don't know how?
• Are you confused about what to eat and what is a true carbohydrate?
• Do you exercise but don't seem to lose weight?

If you answered yes to any of these questions "The Metabolism of Weight Loss" can help!

Some of the subjects include

• what is insulin
• what is glucagon
• what does insulin do
• what does glucagon do
• how does the body lose weight
• how does the body put on weight
• stomach hunger
• the incomplete food cycle
• glucagon and fat burning
• why you shouldn't rely on exercise
• the fallacy of multiple small feedings
• why eating breakfast may not be good for you
• epinephrine and norepinephrine
• the dangers of sucrose (table sugar)
• the dangers of sports nutrition

arm yourself with real knowledge

When you understand more about how human energy metabolism keeps us going, you will be able to better evaluate and judge your own diet plan, foods and food labels. You will know what to do when a few pounds start to come back and what not to do. You won't be fooled by diets that claim you can eat all you want all day long and still be thin. There is a certain comfort in knowing the real "math" on human energy metabolism that makes it much easier to permanently modify bad eating habits. You may not quit them completely, but you will be able to control them so they don't affect your health and your weight.

final exam and review

When you feel ready you can take the final exam. We had this exam online for a month and the high non-adjusted score was 60. See if you can beat this. Just by taking the exam you will learn a lot about insulin, glucagon, weight loss and exercise.

Why is this woman starving?

Demonstration of the relationship
between malnourishment and obesity.

Act Now and get the "Metabolism of Weight Loss" for only $37!

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60 Day No Questions Guarantee

If you are not completely satisfied you can obtain a full refund of the purchase price, no questions asked for 60 days following the date of your purchase.

System Requirements

• college level or above reading ability
• one regular dictionary and one medical dictionary
• serious desire to improve your health

The e-books are in pdf format and require Adobe Reader which can be downloaded from Adobe for free download Adobe Reader.

Thank you for visiting the "Metabolism of Weight Loss."

John Mericle M.D. D.A.B.R.